The Department of Health and Human Services has issued a new request for information seeking public input on how artificial intelligence can be more rapidly adopted in clinical care to reduce costs, improve outcomes and ease provider burden across the U.S. healthcare system.
HHS said Friday that stakeholders are invited to share perspectives on how it can better use its regulatory, reimbursement and research authorities to enable practical, safe AI deployment. The effort is being led by the HHS Office of the Deputy Secretary as part of a broader push to extend the department’s AI strategy beyond internal operations.

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What Outcomes Is HHS Seeking From AI Use in Healthcare?
The agency is particularly interested in how AI tools could enhance patient and caregiver experiences, improve care quality and deliver efficiency gains that help lessen healthcare spending for consumers and government programs. Respondents are also encouraged to discuss how existing digital health and software regulatory frameworks may need to evolve to accommodate AI-driven tools while ensuring patient safety.
Another focus area is reimbursement. HHS is seeking feedback on how payment structures could be simplified or better aligned to support technologies that reduce administrative workload and enable more efficient care delivery. The RFI also inquires about how federal research and development investments can enhance implementation science and establish best practices, particularly in complex or high-acuity clinical environments.
“We want to hear from you,” said HHS Deputy Secretary Jim O’Neill. “Our efforts to accelerate AI adoption must be guided by the real needs and experiences of those developing these tools and delivering care.”
The RFI complements HHS’ recently released AI strategy, which outlines a “OneHHS” framework for modernizing care delivery, strengthening governance and advancing research through responsible AI use.
